The Story of Ozone
10: Hyperthermia

CLINICAL EXPERIENCE WITH HYPERTHERMIA JOURNAL OF ONCOLOGY, 1993
INDIANA UNIVERSITY MEDICAL CENTER ABSTRACT

The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Indiana.

All patients had previously "failed" conventional radiation therapy, chemotherapy and surgery.

Temperatures attained during the course of therapy on each patient were averaged and the results were evaluated for complete, partial or no response.

Responses were defined as:

1) Complete response: Lesions completely disappeared during treatment and response was maintained for a minimum of six months

2) Partial response: Lesions that were reduced in size more than 50%

3) No response: Less than 50% reduction in tumor size during the treatment

Response varied somewhat according to histology and anatomical site of treatment; however:

• complete response was achieved in 45%
• partial response in 48%
• and no response in 7% of the patients.

The response achieved varied with temperature attained and a minimum temperature of 40 degrees C for 40 minutes produced the greatest number of responses. Response to hyperthermia was directly related to the temperature achieved and the length of time the temperature was applied.

Valley Cancer Institute
304-12099 W. Washington Blvd. Los Angeles, California

"Hyperthermia is the clinical application of therapeutic heat in the treatment of disease. Today hyperthermia is recognized as a standard treatment in the management of malignant tumors. It is especially recommended for metastatic tumors where other treatment methods have a poor history of success.

"Tumor cells have specific environmental requirements, largely dependent on blood flow. When there is an increase in the temperature around the tumor, there is a corresponding increase in the blood flow to that area, as the hypothalamus attempts to regulate body temperature. When heat is applied to the tumor and its surrounding tissue, the temperature rises to destructive levels, because the tightly packed cells of the tumor are not as easily able to cool themselves as the surrounding tissue.

"Repeated heating to 107-113 degrees F. can cause the tumor cells to be killed. Tumor response has been found to be from 40 - 80 %.

"A side benefit of hyperthermia treatment has been substantial pain reduction in a majority of patients.

"Hyperthermia is now an FDA-approved cancer therapy for breast cancer."

- Dr. Haim Bicher

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The Story of Ozone

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